Notably, both the protein levels of LC3 I and LC3 II, and the LC3 II LC3 I ratio increased in beclin 1 knockout cells regardless of irradiation, suggesting either an increase in conversion of LC3 II from LC3 I or a decrease in degradation of LC3 II Fig lasix online However, interpretation of these findings was limited by the absence of standardised diagnostic criteria for Alzheimer s disease, small sample size, brief follow up and poor study design